There are a lot of issues that people have with Koman - one of the biggest being that the products that donate to Koman are products that some researchers say cause breast cancer. There is also their support of silicone breast implants and the fact that now, everything in stores comes in two colors - regular, and pink. I would like to support breast cancer research but I don't want to buy a pink stand mixer to do so. When you buy or register for pink products, remember to think before you pink. (For example, Cook for the Cure products? I'm pretty sure it's a scam to get your email address and other info.)
That being said, Komen is a very good organization to raise awareness, to join survivors together, to organize activists, and they are forward about the fact that only 8% of their money goes to research. They also are nicely set up to do a charity registry. There are several options for online donations. I think the best for a registry is to create your own page. This is a great option for anyone who has lost a loved one to breast cancer.
For favor donations, consider (usually free) vista print business cards (although check with your local Komen because some of them may be able to make them for you) or consider something manufactured like this. Or go the candy-in-a-cellophane-bag route. In October, M&Ms makes pink M&Ms - rebag them in cellophane, attach a piece of cardstock stapled across the top or to a twist tie when you bag it and ta-da! If you are as sick of pink as I am, and go with normal colored candy. Or you could give out pink ribbons for everybody to pin on their clothes. There's a lot of pink crap out there - go wild. (I'm sorry. I know breast cancer is a huge problem and I know survivors and people who have died from it, but I'm so sick of all the pink.)
You can also run your local Race for the Cure as your Wedding Day 5k or for a bachelorette party! (The Maryland race is next weekend in Hunt Valley.)